637 Choroid Plexus Tumours in the Paediatric Population - a Five Year Review

Abstract Aim A systematic, qualitative review of the literature available on choroid plexus tumours (CPTs) in paediatric population, published within last 5 years. Method Medline and Embase databases were used to identify suitable papers, 70 papers eligible for inclusion. Inclusion criteria: (1) Paediatric (2) Choroid lesions any grade, (3) Human subjects, (4) available, (5) Author name (6) English. Results are rare neuroepithelial tumours. It was found that 74% CPTs present first decade life. They have a slight male predilection, with female ratio 1.2:1. The most frequent symptoms this study included headache, vomiting, motor weakness. Both CT MRI images usually demonstrate densely enhancing, multilobulated, intraventricular masses. can be divided into three histological grades been subdivided 3 methylation groups, which is proposed more accurate classification than information alone. management one controversial aspects CPT's. Treatment options include surgical resection, traditional chemotherapy, marrow ablative radiotherapy, depending case. Conclusions Larger cohorts necessary prospective, randomised studies needed develop standardised treatment patients improve outcomes. As many low incidence conditions, there appears vicious cycle incidences poor outcomes, perpetuate limited research area alongside clinical need better management.